Hudson Valley Lyomac
  • Freeze Dryers
    • Stratus MP3® Large Freeze Dryer
    • Trilogy® Series Freeze Dryer
    • Trident® Series Freeze Dryer
    • Futura® Series Freeze Dryer
    • BT-1000 ® Lab Benchtop Freeze Dryer
    • Industrial Freeze Dryers
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  • Dual Condenser
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  • Quality In Freeze Drying
  • Quantifying Vial Capping Process - Webinar
  • Complex Injectables - Webinar
  • Deuterium Exchange - Webinar
  • Continuous Lyophilization - Webinar
  • Lyophilized Drug Appearances
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WEBINAR

Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS):
A new analytical method to accelerate the development of lyophilized protein drug products and processes.
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About our speaker: Elizabeth Topp
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Elizabeth (Liz) Topp is a professor in the Department of Industrial and Physical Pharmacy. She holds a bachelor’s degree in chemical engineering from the University of Delaware, a master’s degree in chemical and biochemical engineering from the University of Pennsylvania, and a Ph.D. in pharmaceutics from the University of Michigan. Her research is concerned with the stability and formulation of protein drugs, with particular emphasis on lyophilized solids.
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WEBINAR DESCRIPTION: The development of lyophilized protein drug products, and of the lyophilization processes that produce them, depends on time-consuming shelf-stability studies to assure product quality. These studies can take months to years to complete. Our group has developed ssHDX-MS to measure protein structure and matrix interactions in lyophilized solids with high resolution. Recently, we have shown that ssHDX-MS results are highly correlated with shelf-stability for a monoclonal antibody. In addition, we have shown that ssHDX-MS is sensitive to both process and formulation differences  that are not detected by other methods. Since ssHDX-MS studies can be completed in weeks rather than months or years, the method shows promise as a surrogate for stability studies in developing lyophilized protein drug products and processes. This webinar will describe the ssHDX-MS method and summarize our results.
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​LyoHUB, an industry consortium to advance lyophilization technology, will also be presented briefly.


Ordering and Technical Information

Hudson Valley Lyomac maintains a staff of qualified Field Service Engineers that provide technical assistance for the installation, commissioning, repair, and maintenance of  Hudson Valley Lyomac freeze-dryers. Our technical support centers are located in Europe and the US, as well as in key regional Customer Centers worldwide. 
CONTACT LYOMAC
Need Help? 

Have a question? Need Our Assistance?
Email: sales@hudsonvalleylyomac.com
Phone: 518-828-2180 / 800-836-0744 

​Mailing Address
Hudson Valley/Lyomac
793 Route 66
Hudson, NY 12534 USA

  • Freeze Dryers
    • Stratus MP3® Large Freeze Dryer
    • Trilogy® Series Freeze Dryer
    • Trident® Series Freeze Dryer
    • Futura® Series Freeze Dryer
    • BT-1000 ® Lab Benchtop Freeze Dryer
    • Industrial Freeze Dryers
  • Pharmaceutical
    • COVID-19
  • Laboratory
  • Dual Condenser
  • TESTIMONIALS
  • About Us
    • WORK WITH US
  • Contact
    • Request a Quote
  • Quality In Freeze Drying
  • Quantifying Vial Capping Process - Webinar
  • Complex Injectables - Webinar
  • Deuterium Exchange - Webinar
  • Continuous Lyophilization - Webinar
  • Lyophilized Drug Appearances
  • Refurbished Freeze Dryers
  • Freeze Dryer Size Calculators
  • Legal